Jun 2, 2023
This episode features Matthew Baggott of Tactogen Inc. and will explore entactogens, which are drugs like MDMA, 2C-B, and Methalone.
We start with setting a basic framework for what an entactogen is and a few example drugs, before exploring the complexities in their various effects, mechanisms of action, and both the legislative and technical process of the development of novel or new entactogenic drugs.
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For links to Baggott's work, full show notes, and a link to watch this episode in video, head to bit.ly/ATTMind177
*** FULL TOPICS BREAKDOWN BELOW**
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Episode Breakdown
- (0:00) Opening
- (2:44) Guest Bio
- (4:06) Patreon thanks | Support The Show
- (5:42) Interview begins
- (6:31) What is an entactogen and what does it do? | The difference between entactogens and psychedelics
- (8:37) A short discussion about 2C-B
- (11:47) A list of different entactogens
- (15:30) r-MDMA vs s-MDMA
- (19:48) Methalone, aka bk-MDMA
- (21:52) 3-MMC and 4-MMC: patents, development, and legality
- (23:13) Why Schedule 1 makes drug development difficult
- (25:02) The qualities they are trying to design OUT of new entactogen drugs (pt1)
- (26:31) “The loss of magic” with MDMA
- (33:11) Serotin transporters and MDMA neuro-oxidization
- (36:27) Using NAC to bring back the MDMA magic | enhanced plasticity, antioxidants, and homeostasis
- (44:13) The qualities they are trying to design OUT of new entactogen drugs (pt2)
- (48:52) Why we need “take home” entactogenic drugs
- (53:20) Can a drug still be medicine if it’s fun, too?
- (58:13) The process of justifying off-label MDMA prescriptions
- (1:03:01) Will there be a moral backlash against the development of “good feel” drugs?
- (1:11:10) The negative social consequences of prohibitionist law enforcement
- (1:15:58) We can’t just give people psychedelics and expect society will get better
- (1:18:46) Problematic moves in the psychedelic biotech industry
- (1:25:01) Psychedelic Patent Trolling
- (1:32:15) How Tactogen is trying to give back to psychedelic users
- (1:44:16) Increasing access to health care, not just to psychedelic substances
- (1:49:40) Follow-up link and contact details
- (1:51:25) closing